A psychedelic state arises from desynchronized brain activity
Smith et al. (1999) similarly found that tolerance to the discriminative stimulus effect of DOI in rats correlated with downregulation of 5-HT2A receptors, but they observed no change in density of 5-HT2C receptors. Short agonist treatment also led to desensitization of 5-HT2A receptor–mediated phosphoinositide (PI) hydrolysis in transfected cell lines (Ivins and Molinoff, 1991; Roth […]
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